Analysis Note

Colour (visual): white to yellow to beigeAppearance of substance (visual): beadsLoading (determined from the substitution of the Fmoc-Leu loaded resin): 0.40 - 1.00 mmol/gSwelling Volume (in DMF): lot specific resultThe polymer matrix is copoly ( styrene - 1% DVB ) 100- 200 mesh

General description

This support consists of MBHA resin functionalized with Riniker′s hyperacid-labile 4-hydroxymethyl-3-methoxyphenoxybutyric acid linker [1].

This hyperacid-sensitive resin is a useful tool for the Fmoc SPPS of protected peptide acid fragments.

Attachment of carboxylic acids is normally achieved by DMAP catalyzed esterification with the appropriate symmetrical anhydride, or by using 2,6-dichlorobenzoyl chloride/pyridine [2] or MSNT/Melm activation [3, 4, 5].

Detachment of these functionalities can be effected by treatment with 1-5% TFA in DCM.

The product number for this product was previously 01-64-0036.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Linkage

Replaces: 01-64-0036